[Drug effects on gallbladder motility (based on dynamic ultrasonic data)]. / O lekarstvennykh vliianiiakh na motoriku zhelchnogo puzyria (po materialam ul'trazvukovoi dinamiki).

Ultrasound registration of changes in gallbladder volume by the method of cylinder sum allows reliable means of studying gallbladder contractility in response to pharmacological load. Cerucal increased this activity in chronics with gastroduodenitis and diabetes mellitus, pentagastrin reduced the gallbladder volume. In duodenal ulcer patients a single dose of dalargin dilated the gallbladder for a short time, while in course treatment did not influence it. Gastrocepin inhibited motor activity of gallbladder as well as corinfar.

[Role of health centers in reduction of morbidity in women employed in the construction industry]. / Zabolevaemost zhenshchin, rabotaiushchikh v stroitelnom proizvodstve, i rol ozdorovitelnykh tsentrov v eë snizhenii.

The study covered the health status of 4500 women of various building occupations. Locomotor diseases turned out to take the first place among other somatic diseases. Disorders of larynx, ear and nose are widely spread. Chronic tonsillitis and its decompensation, pharingolaryngitis, otitis are more frequent and more severe in women engaged into production. The allergic dermatoses diagnosed in female builders were proved to be occupational. Female engineering staff has higher prevalence of gastrointestinal, cardiovascular, neural and urinary diseases. For better health of women engaged into the building industry the measures of improving the work conditions and special therapeutic rehabilitation for the risk group were suggested.

[Comparative study of the action of Finoptin, Korinfar and Capoten in patients with stage II hypertensive disease]. / Sravnitel'noe izuchenie aktivnosti finoptina, korinfara i kapotena u bol'nykh gipertonicheskoi bolezn'iu vtoroi stadii.

The effects of Finoptin, Corinfar, and Capoten were examined in 154 patients with Stage II hypertensive disease. The calcium antagonists Finoptin and Corinfar, as well as Capoten were equal in lowering blood pressure and having a heterodirectional action on cardiodynamics: Finoptin exerted a positive inotropic effect in 46.3% and a negative one in 53.7%, corinfar in 66.7 and 33.3%, respectively, and Capoten in 37.5 and 62.5%. The baseline hemodynamic type fails to predict how the myocardium in a particular patient will respond to the antihypertensive drug. Nevertheless, Corinfar is more preferable in patients with hypertensive disease attended by hypokinetic circulation, Capoten is more preferable in those with its hyperkinetic variant. The baseline hemodynamic type makes an insignificant contribution to the activity of Finoptin.

[Comparison of the hemodynamic effects of Corinfar in patients with neurocirculatory dystonia and hypertensive disease]. / Sravnitel'noe vliianie korinfara na gemodinamiku u bol'nykh neirotsirkuliatornoi distoniei i gipertonicheskoi bolezn'iu.

Echocardiography was used to study the cardio- and hemodynamic effects of corinfar in 22 patients with neurocirculatory dystonia and 24 with hypertensive disease. The agent showed a pronounced hyperdynamic effect in patients with neurocirculatory dystonia, whereas it significantly lowered systolic, diastolic, mean blood pressures in those with hypertensive disease, by facilitating left ventricular performance without hyperkinemia. It is concluded that neurocirculatory dystonia and hypertensive disease are different diseases, by judging from the cardio- and hemodynamic effects of the calcium antagonist in these patients.

[Are the results of intragastric pH-metry and measurements of the pH of extracted gastric juice comparable?]. / Ravnoznachny li resul'taty vnutrizheludochnoi pH-metrii i izmereniia pH izvlechennogo zheludochnogo soka?

Fundal pH and pH of withdrawn gastric juice were measured under basal condition (with no stimulants used) in normal subjects and patients with chronic moderately severe and marked fundal gastritis and duodenal ulcer (altogether 96 examinees). Aspiration pH-metry with a tube designed by Ye. Yu. Linar was employed. Comparison of the results revealed statistically significant differences (the 'agreement criterion') in the pH values obtained by the compared methods. Low pH values were more frequent in intragastric fundal pH-metry, possibly at the expense of the presence of not only acid but of the antral-alkaline component in the withdrawn gastric juice. These differences should be taken into consideration in the clinical laboratory diagnosis.

[The hemodynamic reactions of hypertension patients taking the calcium antagonists finoptin and korinfar]. / Gemodinamicheskie reaktsii u bol'nykh gipertonicheskoi bolezn'iu na priem antagonistov kal'tsiia finoptina i korinfara.

As many as 98 patients suffering from essential hypertension (EH) were examined for the effects of verapamil and nifedipine. The hemodynamics and heart contractility were estimated by means of echocardiography on an "Aloka D-280" outfit (Japan). The following parameters of the cardio- and hemodynamics were computed: the stroke and minute blood volumes, cardiac index, mean velocity of ventricular evacuation, performance of the left heart, energy consumption by the myocardium, arterial pressure (systolic, diastolic and mean), total peripheral vascular resistance, ejection fraction, and the rate of circulatory shortening of myocardial fibers. Analysis of the effects of verapamil and nifedipine on the cardio- and hemodynamics in EH patients has demonstrated that in addition to their unidirectional action manifested by a steady hypotensive effect, the drugs under consideration produced an action of different directions as regards certain essential parameters in a considerable number of the patients.

[Aspiration pH-metry of the stomach by the Linar technic--an optimal method of studying gastric secretion]. / Aspiratsionnaia pH-metriia zheludka po E.Iu. Linaru--optima'lnyi metod izucheniia zheludochnoi sekretsii.

Discussion is devoted to the advantages of intragastric pH-metry and gastric probe study in aspiration pH-metry of the stomach. Data are given on the means of decoding the results of pH-metry. Aspects of the examination of gastric secretion that contribute both to research and clinical practice are discussed.

[Effects of pentagastrin in patients with diabetes mellitus]. / Effekty pentagastrina u bol'nykh sakharnym diabetom.

Pentagastrin used in patients with diabetes mellitus at a dose necessary for a study of gastric secretion regularly enhances the blood flow in the gastric mucosa and liver raising absorptive and antitoxic liver function.

[Clinical pharmacology of agents affecting the tonus of the lower esophageal sphincter]. / K klinicheskoi farmakologii sredstv, vliiaiushchikh na tonus nizhnego sfinktera pishchevoda.

The effect of pharmacological drugs indicated for specific diseases on the lower esophageal sphincter, was studied in 195 patients. Pentagastrin increased the sphincter tone, secretin when used in peptic ulcer, did not influence the tone. Unlike atropine, a therapeutic course with pirenzepine (gastrozepin) for patients with peptic ulcer did not lower the tone of the lower esophageal sphincter. Diazepam significantly decreased indices of the sphincter tone. In the treatment of CHD patients with corinfar, a calcium antagonist, the sphincter tone was on a moderate but statistically significant decrease. Aminophylline in patients with chronic bronchitis made no effect on this index. The ratio of the sphincter tone stimulated with metoclopramide to its basal values was higher in the patients with initially lowered indices as compared to the patients in whom the initial tone was within normal.